This pioneering study investigated the partial derivatives of the dependence of the compression modulus of ice-six on pressure and temperature, and the coefficient of volume expansion on the temperature at high pressure and low temperature. Ice six is documented on the phase diagram between the pressures 600 and 2000 MPa and between the temperatures 110 and 330 K. The pressure and temperature dependence of the all-round compression module was practically implemented in a multilayer cylinder-piston vessel. The change in the relative volume of the sample was measured using a transducer which converts linear translational motion into electrical pulses. The pressure of the sample was measured by measuring the electrical resistance of tin and gallium conductors and phase transition points of polymorphic ice modifications. The temperature of this ice-six modification was determined by a graduated copperconstantan thermocouple. Moreover, in this paper, the Debye characteristic temperatures of ice-six and the Gruneisen constant are estimated.